1. However, Coexistence of triplicated alpha-gene with beta-thalassaemia trait increases the severity of this conditions

2. Antenatal screening tests Antenatal screening tests include screening for sickle cell disease and thalassaemia, infectious diseases, the 20-week scan and screening for Down's syndrome

3. The emergence of the aberrant mutant T in malaria - ridden countries is now believed to be an evolutionary counterblast to malaria . For it seems that in a malarial region it is an advantage to have the thalassaemia trait .

4. Bossing: Rounded prominence of the frontal and parietal bones in an infant’s cranial vault, due to various causes Aetiology Untreated vitamin D-induced rickets, which causes a thickened outer table with permanent enlargement of the head, congenital anemia—e.g., thalassaemia with massive hematopoiesis in an expanded marrow space, aka ‘hot cross