1. Thus, Alloxan may have caused beta cell destruction

2. Islet Arnt increases in normal murine pregnancy and beta-cell Arnt is required for cyclinD2 induction and increased beta-cell proliferation in pregnancy

3. The process of beta-cell destruction, marked by the production of Autoantibodies to the beta-cell, occurs over many years and ultimately results in metabolic abnormalities first manifested as impaired glucose tolerance and then progressing to symptomatic hyperglycemia

4. A major study outcome was identification of the clock gene Rev-erb-alpha as a regulator of pancreatic beta-cell function.

5. As such, dysregulation of Rev-erb-alpha expression during obesity may result in altered beta-cell function and, eventually, type 2 diabetes.

6. Beta cell selectivity of Alloxan Alloxan is a very unstable chemical compound [23] with a molecular shape resembling glucose (Fig.2)[24, 25]

7. 7 The viruses primarily infected the exocrine cells, and each one carried a different gene known to play a role in beta cell development.

8. Alloxan's harmful effects on the pancreas are so severe that the Textbook of Natural Medicine calls the chemical "a potent beta-cell toxin." However, even though the toxic effect of Alloxan is common scientific knowledge in the research community, the FDA still allows companies to use it …