1. Anasarca, asthenia, chest tightness, chest discomfort

2. Other frequent anomalies included cleft palate, anasarca and skeletal anomalies of the vertebrae and ribs

3. In the advanced stages it also extends to the pleural cavity and peritoneum (ascites) and can even develop into a generalized anasarca.

4. Autopsy findings included anasarca, bilateral pleural effusions, ascites and hepatosplenomegaly as well as multiple, up to pinhead sized, white granulomas on the surface of liver, spleen and lungs.

5. When adefovir was administered intravenously to pregnant rats at doses associated with notable maternal toxicity (systemic exposure # times that achieved in humans at the therapeutic dose) embryotoxicity and an increased incidence of foetal malformations (anasarca, depressed eye bulge, umbilical hernia and kinked tail) were observed